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Description

Specifically, colistin significantly promotes the upregulation of HDAC1 expression and leads to the deacetylation of histone 3 lysine 27 (H3K27) in the Nrf2 (the master regulator of anti-oxidant response) promoter region to inhibit the activity of the Nrf2 signaling pathway

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The mechanism appears to involve both an anti-inflammatory effect on melanocytes and normalization of the barrier function

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